منابع مشابه
Mechanisms of immunosuppression by organotins
Mechanisms of immunosuppression by organotins – apoptosis vs. proliferative arrest-Proefschrift Universiteit Utrecht. Met een samenvatting in het Nederlands. Con un riassunto in Italiano. CONTENTS Chapter 1 General Introduction 5 Chapter 2 Organotin-induced apoptosis as observed in vitro is not relevant for induction of thymus atrophy at antiproliferative doses Chapter 3 Organotin-induced apopt...
متن کاملEffects of Organotins on Crustaceans: Update and Perspectives
Organotins (OTs) are considered some of the most toxic chemicals introduced into aquatic environments by anthropogenic activities. They are widely used for agricultural and industrial purposes and as antifouling additives on boat hull's paints. Even though the use of OTs was banned in 2008, elevated levels of OTs can still be detected in aquatic environments. OTs' deleterious effects upon wildl...
متن کاملEnvironmental obesogens: organotins and endocrine disruption via nuclear receptor signaling.
Over the last two decades, the incidence of obesity and associated metabolic syndrome diseases has risen dramatically, becoming a global health crisis. Increased caloric intake and decreased physical activity are believed to represent the root causes of this dramatic rise. However, recent findings highlight the possible involvement of environmental obesogens, xenobiotic chemicals that can disru...
متن کاملHuman exposure, biomarkers, and fate of organotins in the environment.
Organotin compounds result from the addition of organic moieties to inorganic tin.Thus, one or more tin-carbon bonds exist in each organotin molecule. The organo-tin compounds are ubiquitous in the environment. Organotin compounds have many uses, including those as fungicides and stabilizers in plastics, among others in industry. The widespread use of organotins as antifouling agents in boat pa...
متن کاملThe Proteasome Is a Molecular Target of Environmental Toxic Organotins
BACKGROUND Because of the vital importance of the proteasome pathway, chemicals affecting proteasome activity could disrupt essential cellular processes. Although the toxicity of organotins to both invertebrates and vertebrates is well known, the essential cellular target of organotins has not been well identified. We hypothesize that the proteasome is a molecular target of environmental toxic ...
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ژورنال
عنوان ژورنال: Nature
سال: 1972
ISSN: 0028-0836,1476-4687
DOI: 10.1038/237118b0